Protein Modification Reagents
Medchemexpress LLC Nhpi-peg4-c2-nhs ester | 1415328-95-8 | MFCD28155511 | 98.9% | 508.48 g/mol | C23H28N2O11 | 1 G
NHPI-PEG4-C2-NHS ester is a PEG-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is supplied for research use and has a molecular weight of 508.48 g/mol and formula C23H28N2O11. Store the pure material at -20°C; observe low-temperature storage for solutions.
Medchemexpress LLC m-PEG20-alcohol 1g
m-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
![eMolecules Broadpharm / DBCO-PEG2-PFP ester / 100mg / 448298236 / BP-24326 / 98.000 / 2304558-23-2 / [null] / 630.568 / C32H27F5N2O6](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502477062.JPG-250.jpg)
eMolecules Broadpharm / DBCO-PEG2-PFP ester / 100mg / 448298236 / BP-24326 / 98.000 / 2304558-23-2 / [null] / 630.568 / C32H27F5N2O6
Broadpharm / DBCO-PEG2-PFP ester / 100mg / 448298236 / BP-24326 / 98.000 / 2304558-23-2 / [null] / 630.568 / C32H27F5N2O6
Medchemexpress LLC Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane | 1421933-29-0 | 97.0% | C36H66N4O14 | 100 MG
Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group. This enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with Alkyne-containing molecules and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups. PROTACs leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features an Azide group
- Enables CuAAc and SPAAC reactions
- Supports PROTACs in degrading target proteins
eMolecules AA Blocks LLC Fmoc-N-amido-PEG4-acid 100mg 410171201 AA0038KJ 0 000 557756-85-1 MFCD06656472 487 549 C26H33NO8
AA Blocks LLC Fmoc-N-amido-PEG4-acid 100mg 410171201 AA0038KJ 0 000 557756-85-1 MFCD06656472 487 549 C26H33NO8
eMolecules Maleimide-NH-PEG8-CH2CH2COONHS Ester | 756525-93-6 | 1G | Purity: 98%
Broadpharm | Maleimide-NH-PEG8-CH2CH2COONHS Ester | 1G | 756525-93-6 | MFCD21648521 | MW:63.546
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Cayman Chemical dPE-PEG 2000 MaleImIde 25mg
A MDM2-p53 protein-protein interaction inhibitor (IC50 0.21 nM) selectively inhibits the MDM2-p53 protein-protein interaction over MDM4-p53 YAP1-TEAD4 PCSK9-LDLR and Bcl-2-Bak interactions in TR-FRET assays (IC50s 3.3 150 50 and 50 UM respectively) inhibits the growth of SJSA-1 cells (GI50 38 nM) induces apoptosis in SJSA-1 cells at 100 nM induces tumor regression and prevents tumor regrowth in an SJSA-1 rat xenograft model and an HSAX2655 PDX rat liposarcoma model at 27 mg/kg
Medchemexpress LLC 2-amino-n-(14-azido-2,5-dioxo-9,12-dioxa-3,6-diazatetradecyl)acetamide | 2222277-20-3 | 95.0% | 345.35 g/mol | C12H23N7O5 | 1 ML
Gly-Gly-Gly-PEG2-azide is an azide-functionalized peptide-PEG linker supplied as a ready-to-use solution (10 mM in DMSO, 1 mL) or as a solid. It is intended for use in antibody-drug conjugate synthesis, bioconjugation, and related chemical biology applications.
- Azide-functionalized peptide-PEG2 linker for bioconjugation.
- Available as 10 mM solution in DMSO (1 mL) or solid forms.
- Used for antibody-drug conjugate synthesis and related chemistry.
- Characterized by CAS 2222277-20-3 and molecular weight 345.35 g/mol.
Cayman Chemical ANTIBODY DBCO acId 50mg
A copper-free click chemistry reagent; has been used in the study of glycoprotein charge effects on the migration and invasion of 9-azido sialic acid-labeled cancer cells in vitro; has also been used in the synthesis of DBCO-modified RNase A to deliver RNase A into AAM-labeled cancer cells in vitro and in vivo to induce cytotoxicity and reduce tumor growth, respectively
![eMolecules Broadpharm / endo-BCN-PEG8-amine / 100mg / 795361837 / BP-40206 / 98.000 / / [null] / 588.739 / C29H52N2O10](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472886.JPG-250.jpg)
eMolecules Broadpharm / endo-BCN-PEG8-amine / 100mg / 795361837 / BP-40206 / 98.000 / / [null] / 588.739 / C29H52N2O10
Broadpharm / endo-BCN-PEG8-amine / 100mg / 795361837 / BP-40206 / 98.000 / / [null] / 588.739 / C29H52N2O10
![eMolecules Broadpharm / TCO-PEG6-NHS ester / 25mg / 433947019 / BP-24156 / 95.000 / 2353409-96-6 / [null] / 602.678 / C28H46N2O12](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502503034.JPG-250.jpg)
eMolecules Broadpharm / TCO-PEG6-NHS ester / 25mg / 433947019 / BP-24156 / 95.000 / 2353409-96-6 / [null] / 602.678 / C28H46N2O12
Broadpharm / TCO-PEG6-NHS ester / 25mg / 433947019 / BP-24156 / 95.000 / 2353409-96-6 / [null] / 602.678 / C28H46N2O12
STA PHARMACEUTICAL US LLC Fmoc-amino-PEG3-CH2COOH | 1 g | CAS 139338-72-0 | MDL MFCD13182400
Fmoc-amino-PEG3-CH2COOH is a Amino Acid reagent (Subcategory: PEG AA) sold by WuXi TIDES. Offered in 1 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 139338-72-0
- MDL: MFCD13182400
- InChIKey: XNOJSAOJCBOZTA-UHFFFAOYSA-N
- Molecular Weight: 429.469
- Molecular Formula: C23H27NO7
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 7.8 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: 1-(9H-fluoren-9-yl)-3-oxo-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid
- SMILES: O=C(COCCOCCOCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)O
Medchemexpress LLC Propargyl-PEG4-GGFG-DXd | 2762518-94-3 | 100.0% | 1083.12 g/mol | C54H63FN8O15 | 5 MG
Propargyl-PEG4-GGFG-DXd is a drug-linker conjugate for antibody-drug conjugate (ADC) research that couples a cleavable GGFG peptide-PEG4 linker with a propargyl handle to the DXd topoisomerase I inhibitor. It is supplied as an off-white to light yellow solid, with high purity and DMSO solubility for use in conjugation and payload studies.
- High purity, 99.99% (HPLC)
- Molecular weight 1083.12 g/mol
- Chemical formula C54H63FN8O15
- Physical appearance: solid, off-white to light yellow
- Storage: 4°C as supplied; in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
- Solubility: DMSO up to 100 mg/mL (use ultrasonic)
- Intended use: research use only for ADC linker-payload development